Temporal Modulation of Type I Interferon and NF-κB Signaling by Baicalin Suppresses Infectious Bronchitis Virus Replication and Inflammatory Response
Baicalin suppresses IBV replication through coordinated enhancement of type I interferon response and temporal regulation of NF-κB pathway, with IRF3 serving as a key regulatory molecule. These findings provide mechanistic support for baicalin's potential as an anti-IBV therapeutic agent.
Authors
- Jiongjie He (ORCID: https://orcid.org/0000-0003-0066-4723)
- Shengyi Wang (ORCID: https://orcid.org/0000-0001-5195-5059)
- Lingling Wang (ORCID: https://orcid.org/0000-0003-0272-2974)
- Yong Zhang (ORCID: https://orcid.org/0000-0002-2692-5437)
Institutions
- Gansu Agricultural University (CN)
- Lanzhou Institute of Husbandry and Pharmaceutical Sciences (CN)
Publication Details
- Journal
- Animals
- Published
- 2025-11-25
- DOI
- https://doi.org/10.3390/ani15233396
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00