Increased plasma concentrations of acyl-coenzyme A binding protein (ACBP) predict future lung cancer development in smokers at risk of cardiovascular disease
These findings independently validate ACBP/DBI as a circulating biomarker of future LC development in at-risk individuals. Clinically, ACBP/DBI quantification could refine risk-adapted lung cancer screening strategies, guiding the frequency of low-dose CT scans and identifying candidates for preventive interventions, including potential ACBP/DBI-neutralizing therapies.
Authors
- Marine Fidelle (ORCID: https://orcid.org/0000-0002-5589-9688)
- Magalie Martineau (ORCID: https://orcid.org/0000-0003-1817-2372)
- David Boulate (ORCID: https://orcid.org/0000-0003-4757-4565)
- Hui Chen (ORCID: https://orcid.org/0000-0002-1260-8617)
- Pamela Abdayem (ORCID: https://orcid.org/0000-0002-4477-3633)
- Kuznetsova Tv (ORCID: https://orcid.org/0000-0001-5403-3885)
- Laurence Zitvogel (ORCID: https://orcid.org/0000-0003-1596-0998)
- Léa Montégut (ORCID: https://orcid.org/0000-0003-4778-4757)
- Harry J. de Koning (ORCID: https://orcid.org/0000-0003-4682-3646)
- Carlijn M. van der Aalst
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Aix-Marseille Université (FR)
- Université Paris-Saclay (FR)
- Institut Gustave Roussy (FR)
- Sorbonne Université (FR)
- Sorbonne Paris Cité (FR)
- Centre de Recherche des Cordeliers (FR)
- La Ligue Contre le Cancer (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Européen (FR)
- Hôpital Nord (FR)
- Hôpital Marie Lannelongue (FR)
- Erasmus University Rotterdam (NL)
- KU Leuven (BE)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1186/s12943-025-02507-3
- Citations
- 1
- Primary Topic
- Peroxisome Proliferator-Activated Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- European Commission
- Agence Nationale de la Recherche
- Ligue Contre le Cancer
- China Scholarship Council
- Université de Paris
- HORIZON EUROPE Framework Programme