Dickkopf-3 enhances the chondroprotective effect of chondrogenic progenitor cells in a rat model of posttraumatic osteoarthritis
Our results suggest that DKK3 has a chondroprotective effect during osteoarthritis progression and that CPCs may be functional targets. The underlying mechanisms of DKK3 may include enhancing CPC chondrogenic capacity and inhibiting Wnt-mediated expression of catabolic factors and matrix remodelling activities. These findings indicate that DKK3 is a potential therapeutic target for CPC-mediated OA treatment.
Authors
- Jianhui Xu (ORCID: https://orcid.org/0000-0001-6330-7948)
- Zhongli Li (ORCID: https://orcid.org/0000-0001-7477-5392)
- Zhidong Zhao (ORCID: https://orcid.org/0000-0003-4672-7873)
- Heng Zhu (ORCID: https://orcid.org/0000-0002-8408-3821)
- Xu Shi (ORCID: https://orcid.org/0000-0002-9675-4186)
- Ya Huang
- Yuxing Wang
Institutions
- Jiangsu University (CN)
- People's Liberation Army No. 150 Hospital (CN)
- Affiliated Hospital of Jiangsu University (CN)
- Beijing Radiation Center (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1186/s13018-025-06470-z
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00