Immune cell-resolved transcriptomics provides insights into the basis for variations of fish genetic resistance to viral disease
This study reveals the contribution of the core set of interferon-stimulated genes conserved across vertebrates to the response of different immune cells and the response of other genes in resistant and susceptible fish. It provides a comprehensive basis for evolutionary studies of resistance to viruses in vertebrates.
Authors
- Bertrand Collet (ORCID: https://orcid.org/0000-0003-2795-2653)
- Valentin Thomas (ORCID: https://orcid.org/0000-0001-6746-2857)
- Pierre Boudinot (ORCID: https://orcid.org/0000-0002-7490-9677)
- Thomas Curtis Clark
- Samuel Martín (ORCID: https://orcid.org/0000-0003-0289-6317)
- Daniel J. Macqueen (ORCID: https://orcid.org/0000-0001-8050-7722)
- Audrey Laurent (ORCID: https://orcid.org/0000-0002-7643-6017)
- Delphine Lallias (ORCID: https://orcid.org/0000-0002-1609-0827)
- Richard S. Taylor (ORCID: https://orcid.org/0000-0003-1417-715X)
- Mathieu Charles
- Isabelle Schwartz‐Cornil
Institutions
- Roslin Institute (GB)
- University of Aberdeen (GB)
- Université de Versailles Saint-Quentin-en-Yvelines (FR)
- Université Paris-Saclay (FR)
- Microbiologie de l’alimentation au service de la santé (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Virologie et Immunologie Moléculaires (FR)
- Laboratoire de Physiologie et Génomique des Poissons (FR)
- University of Edinburgh (GB)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1186/s12915-025-02452-z
- Primary Topic
- Aquaculture disease management and microbiota
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Agence Nationale de la Recherche
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
- Directorate for Biological Sciences
- Biotechnology and Biological Sciences Research Council