Epigenomic characterization and therapeutic challenges of melanoma arising in giant nevi in pediatric patients
MM arising within CGMN poses diagnostic and therapeutic challenges. While molecular and epigenomic profiling supports accurate classification and understanding of disease biology, the role of immunotherapy remains uncertain-marked by reduced efficacy and significant immune-related toxicity. A multidisciplinary approach is essential to guide management and improve outcomes in this rare pediatric malignancy.
Authors
- Isabella Giovannoni (ORCID: https://orcid.org/0000-0002-9980-6594)
- Lucia Pedace (ORCID: https://orcid.org/0000-0001-8552-3641)
- Angela Mastronuzzi (ORCID: https://orcid.org/0000-0002-4408-2373)
- Mario Zama (ORCID: https://orcid.org/0000-0003-4241-7392)
- Aurora Castellano (ORCID: https://orcid.org/0000-0002-2316-4927)
- Franco Locatelli (ORCID: https://orcid.org/0000-0002-7976-3654)
- Maria Debora De Pasquale (ORCID: https://orcid.org/0000-0003-1082-6810)
- Evelina Miele (ORCID: https://orcid.org/0000-0002-4747-1032)
- Maria Carmen Garganese
- Francesca Grussu
- Andrea Diociaiuti (ORCID: https://orcid.org/0000-0003-0879-9825)
- Sabina Barresi (ORCID: https://orcid.org/0000-0002-7307-388X)
- Marta Cajozzo (ORCID: https://orcid.org/0000-0002-3732-0273)
- Alessandro Crocoli (ORCID: https://orcid.org/0000-0003-2157-4233)
- May El Hachem (ORCID: https://orcid.org/0000-0002-8145-4797)
- Sara Patrizi (ORCID: https://orcid.org/0000-0003-1898-1516)
- Alessandra Stracuzzi (ORCID: https://orcid.org/0000-0002-7762-196X)
- Sabrina Rossi
- Rita Alaggio
- Flavia Vinciarelli
- Fabio Dell’Otto
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Bambino Gesù Children's Hospital (IT)
- Santobono Children's Hospital (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1007/s12672-025-03965-3
- Citations
- 1
- Primary Topic
- Cutaneous Melanoma Detection and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Ministero della Salute