Non-invasive assessment of activated renal macrophages by imaging of colony-stimulating factor 1 receptor in mouse model with ischemic acute kidney injury
Our findings provide the first evidence supporting the utility of <sup>11</sup>C-CPPC-PET as a clinically-available tool for non-invasive detection of activated renal macrophages, predominantly of the M2 phenotype.
Authors
- Fangfei Hu
- Xinran Zhao (ORCID: https://orcid.org/0000-0001-8698-1134)
- Bin Ji (ORCID: https://orcid.org/0000-0002-9672-6441)
- Xuejing Guan
- Rui Xiong (ORCID: https://orcid.org/0000-0002-8883-4805)
- Sijun Chen (ORCID: https://orcid.org/0000-0002-6316-9810)
- Rong Zhou (ORCID: https://orcid.org/0000-0002-4540-7336)
- Chie Seki (ORCID: https://orcid.org/0000-0002-3222-7125)
- Lin Xie (ORCID: https://orcid.org/0000-0002-6472-322X)
- Nan Zhang (ORCID: https://orcid.org/0009-0008-8653-1043)
- Mei Tian (ORCID: https://orcid.org/0000-0002-7388-3954)
- Yanshan Li
- Ming-Rong Zhang
Institutions
- National Medical Products Administration (CN)
- Fudan University (CN)
- Imaging, Brain, and Neuropsychiatry (FR)
- National Institutes for Quantum Science and Technology (JP)
- Quzhou University (CN)
- Yangpu Hospital of Tongji University (CN)
Publication Details
- Journal
- Journal of Inflammation
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1186/s12950-025-00482-6
- Citations
- 1
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 1.43