Negative pressure wound therapy for combat-related extremity vascular injuries: clinical experience from the war in Ukraine

A two-layer NPWT protocol at -70 to -80 mmHg was a safe and effective adjunct in the staged management of combat-related extremity vascular injuries with extensive soft-tissue defects. This approach is associated with the preservation of vascular reconstructions and limbs, low infection and amputation rates, the mitigation of erosion-related bleeding, and timely wound closure. Prospective multicenter studies are needed to optimise and standardise NPWT protocols in this setting.