Icariin-curcumol inhibits histone H3K18 lactylation and FOXM1 expression to enhance the sensitivity of prostate cancer cells to docetaxel
These findings identify H3K18la-mediated FOXM1 activation as a novel mechanism underlying DTX resistance in PCa. Ica-Cur may represent a promising therapeutic agent by targeting lactylation-dependent epigenetic regulation and FOXM1-driven transcriptional activity, supporting its clinical potential for overcoming chemoresistance.
Authors
- Wenjing Xu (ORCID: https://orcid.org/0000-0001-9109-0133)
- Yalin Chen (ORCID: https://orcid.org/0009-0009-1527-7153)
- Wen S. Sheng (ORCID: https://orcid.org/0000-0002-5425-1185)
- Harry Dang
- Qinghu He (ORCID: https://orcid.org/0000-0003-0838-2720)
- Lingyi Li (ORCID: https://orcid.org/0000-0002-0945-7248)
- Lumei Liu (ORCID: https://orcid.org/0000-0002-9014-757X)
- Xiaopu Yu (ORCID: https://orcid.org/0000-0002-7627-9832)
- Chenyu Zhang (ORCID: https://orcid.org/0000-0003-0049-4234)
- Xiaofeng Huang (ORCID: https://orcid.org/0000-0001-7805-3653)
- Yingqiu Li (ORCID: https://orcid.org/0000-0003-3206-5231)
- Tao Tan (ORCID: https://orcid.org/0000-0001-5403-0887)
- Min Feng (ORCID: https://orcid.org/0000-0001-5024-0537)
Institutions
- Hunan University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Hunan University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1186/s12935-025-03927-3
- Citations
- 2
- Primary Topic
- Medicinal Plant Pharmacodynamics Research
- Type
- article
- Field-Weighted Citation Impact
- 3.11