Niosomal mefloquine and cisplatin in breast cancer: comparative effects on apoptosis and angiogenesis via in vitro and in silico analysis
The niosomal formulation of MEF synergistically enhances CIS efficacy by promoting apoptosis, and suppressing angiogenesis in TNBC. These findings highlight NMEF as a promising chemosensitizer to overcome cisplatin resistance. Future studies should focus on in vivo validation and clinical translation.
Authors
- Zohreh Salari (ORCID: https://orcid.org/0000-0002-8899-5350)
- Mohammad Zarif
- Ehsan Salarkia (ORCID: https://orcid.org/0000-0001-6125-5101)
- Ghazal Mansouri (ORCID: https://orcid.org/0000-0003-3434-9350)
- Aouatef Riahi (ORCID: https://orcid.org/0000-0002-1595-6692)
- Ahmad Khosravi (ORCID: https://orcid.org/0000-0002-1106-3782)
- Samira Sohbati (ORCID: https://orcid.org/0000-0003-3293-6818)
- Elaheh Molaakbari (ORCID: https://orcid.org/0000-0003-1050-6331)
- Mohammad Amin Raeisi Estabragh (ORCID: https://orcid.org/0000-0001-5992-1654)
- Mina Khosravi
- Ali Reza Keyhani
Institutions
- Kerman University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1186/s12885-025-15372-6
- Primary Topic
- Mechanisms of cancer metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00