Hormonal imbalance in umbilical vein cord blood of pregnant women with endometriosis: a propensity score-matched analysis
This is the first study showing that female newborns of women with endometriosis are exposed to higher in utero estradiol compared to controls. This high estrogen low androgens environment may influence fetal programming of reproductive traits and might drive the in utero susceptibility to endometriosis.
Authors
- Elisa Polledri (ORCID: https://orcid.org/0000-0002-9625-3656)
- Paolo Vercellini (ORCID: https://orcid.org/0000-0003-4195-0996)
- Silvia Fustinoni (ORCID: https://orcid.org/0000-0002-0287-7338)
- Enrico Iurlaro (ORCID: https://orcid.org/0000-0003-1452-8706)
- Laura Benaglia (ORCID: https://orcid.org/0000-0002-7404-9830)
- Michele Orsi (ORCID: https://orcid.org/0000-0001-5219-4909)
- Maíra Casalechi (ORCID: https://orcid.org/0000-0003-0015-3157)
- Marco Reschini (ORCID: https://orcid.org/0000-0002-9868-3043)
- Noemi Salmeri (ORCID: https://orcid.org/0000-0002-3239-3799)
- Edgardo Somigliana (ORCID: https://orcid.org/0000-0002-0223-0032)
- Paola Viganò (ORCID: https://orcid.org/0000-0003-3674-5912)
Institutions
- University of Milan (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
Publication Details
- Journal
- Reproductive Biology and Endocrinology
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1186/s12958-025-01467-z
- Citations
- 1
- Primary Topic
- Endometriosis Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- Ministero della Salute