<i> RPGR <sup>ORF15</sup> </i> Mutations Disrupt Lysosomal Lipid Metabolism in Retinal Pigment Epithelium Cells and Cause Retinitis Pigmentosa
RPGRORF15 is essential for maintaining lysosome function and lipid metabolism homeostasis in RPE cells. This finding elucidates the previously unrecognized role of RPGRORF15 in RPE cells. This study provides new insights into the mechanisms underlying RPGR-associated retinal diseases and offers potential therapeutic approaches.
Authors
- Mugen Liu (ORCID: https://orcid.org/0000-0001-5076-8438)
- Liyan Dai (ORCID: https://orcid.org/0009-0008-0381-5789)
- Yuejie Zhu (ORCID: https://orcid.org/0000-0002-6088-8991)
- Yunqiao Han (ORCID: https://orcid.org/0000-0002-1369-4262)
- Xiang Ren (ORCID: https://orcid.org/0000-0002-2962-1922)
- Hualei Hu (ORCID: https://orcid.org/0000-0002-3271-0109)
- Xinhua Shu (ORCID: https://orcid.org/0000-0003-3760-3019)
- Pan Gao (ORCID: https://orcid.org/0000-0003-3366-2118)
- Qunwei Lu (ORCID: https://orcid.org/0000-0003-4390-052X)
- Kui Sun (ORCID: https://orcid.org/0000-0002-2487-4779)
- Jiong Luo (ORCID: https://orcid.org/0000-0002-1722-7565)
- Xiang Chen (ORCID: https://orcid.org/0000-0002-2499-8261)
- Zhaohui Tang (ORCID: https://orcid.org/0000-0002-2823-1009)
- Shanshan Yu (ORCID: https://orcid.org/0000-0002-8748-5877)
- Mengmeng Ren
- Yukan Huang
- Shusheng Wang (ORCID: https://orcid.org/0000-0002-5213-3396)
- Pei Li (ORCID: https://orcid.org/0000-0001-9596-3122)
- James Reilly
Institutions
- Tulane University (US)
- Glasgow Caledonian University (GB)
- Wuhan Union Hospital (CN)
- Union Hospital (CN)
- Wuhan University of Science and Technology (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1167/iovs.66.14.61
- Primary Topic
- Lysosomal Storage Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00