Multi-omics analysis reveal clinical-gut-brain interactions in female ibs patients with adverse childhood experiences
Our findings highlight the unique microbiota and brain networks contributing to a complex interplay of chronic stress as measured by early life adversity, the brain-gut-microbiome system, and IBS pathophysiology which can inform therapeutic targets aimed at mitigating the long-term impacts of early life stress in female IBS patients.
Authors
- Michelle Choy (ORCID: https://orcid.org/0000-0001-7604-8244)
- Lisa A. Kilpatrick (ORCID: https://orcid.org/0000-0003-2148-5214)
- Tien S. Dong (ORCID: https://orcid.org/0000-0003-0105-8063)
- Ming Wei Hung (ORCID: https://orcid.org/0000-0002-8840-3618)
- Alison Church
- Andrea Shin (ORCID: https://orcid.org/0000-0001-7284-3398)
- Lin Chang (ORCID: https://orcid.org/0000-0002-8102-9213)
- Emeran Mayer
- Michelle Binod
- Anthony Tomasevic
Institutions
- University of California, Los Angeles (US)
- UCLA Health (US)
- UCLA Medical Center (US)
- Center for Neurologic Study (US)
- Olive View-UCLA Medical Center (US)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1186/s13293-025-00757-w
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of California, Los Angeles