Neurotrophic factor-α1/carboxypeptidase E regulates critical protein networks to rescue neurodegeneration, defective synaptogenesis and impaired autophagy in Alzheimer’s disease mice
This study uncovered vast actions of NF-α1/CPE in restoring expression of networks of critical proteins including those necessary for maintaining neuronal survival, synaptogenesis and autophagy, while down-regulating many proteins that promote tau and Aβ accumulation to reverse memory loss and AD pathology in 3 × Tg-AD mice. AAV-NF-α1/CPE gene therapy uniquely targets many metabolic levels, offering a promising holistic approach for AD treatment (Graphical Abstract).
Authors
- Y. Peng Loh (ORCID: https://orcid.org/0000-0002-5404-723X)
- Pranav Sharma (ORCID: https://orcid.org/0000-0003-4064-4049)
- Lan Xiao (ORCID: https://orcid.org/0000-0002-0391-6909)
- Xuyu Yang
- Daniel Abebe
Institutions
- CCP Technologies (United States) (US)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
Publication Details
- Journal
- Translational Neurodegeneration
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1186/s40035-025-00520-6
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of Mental Health
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development