Characterization of a novel Jumbo phage JP4 with potential to control pathogenic Escherichia coli
Phage JP4 is a new member of the Asteriusvirus genus. As a lytic jumbo phage with rapid bactericidal activity and strong biofilm degradation capacity, JP4 is a promising therapeutic candidate against E. coli O157:H7 infections. This study provides insights into the diversity and clinical potential of jumbo phages in combating pathogens.
Authors
- Jing Zhou (ORCID: https://orcid.org/0000-0002-5348-1966)
- Xuemei Wei (ORCID: https://orcid.org/0000-0001-9761-5586)
- Shuguang Lu (ORCID: https://orcid.org/0000-0003-0362-8330)
- Xu Xiong (ORCID: https://orcid.org/0000-0001-9292-5059)
- Zhenhui Song (ORCID: https://orcid.org/0000-0002-2558-3164)
- Bo He (ORCID: https://orcid.org/0000-0002-4029-5435)
- Yan Zhao (ORCID: https://orcid.org/0000-0002-3414-1739)
- He Liu (ORCID: https://orcid.org/0000-0001-9671-6457)
- Jing Wang (ORCID: https://orcid.org/0009-0007-7812-8599)
- Gang Li (ORCID: https://orcid.org/0000-0001-6778-2842)
- Kexin Zhang (ORCID: https://orcid.org/0000-0003-4831-2372)
- Jun Deng (ORCID: https://orcid.org/0000-0001-5522-6021)
- Fan Xie (ORCID: https://orcid.org/0000-0003-1012-400X)
- Rui Zhao (ORCID: https://orcid.org/0009-0000-0271-1373)
Institutions
- Southwest University (CN)
- Army Medical University (CN)
- Xinqiao Hospital (CN)
- Southwest Hospital (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1186/s12985-025-03001-4
- Citations
- 2
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 3.43
Funders
- Natural Science Foundation of Chongqing
- Southwest Hospital
- Army Medical University
- Centre Scientifique et Technique du Bâtiment