IGFBP1 facilitates tumor proliferation, invasion and migration by modulating the MAPK-ERK signaling pathway in lung adenocarcinoma
IGFBP1 indicates the promotion of lymph node metastasis in LUAD by facilitating tumor proliferation, invasion, and migration through modulation of the MAPK-ERK signaling pathway. Our findings highlight IGFBP1 as a potential prognostic biomarker, though its therapeutic utility requires validation in preclinical models.
Authors
- Zhenfa Zhang (ORCID: https://orcid.org/0000-0002-9627-2590)
- Mengzhe Zhang (ORCID: https://orcid.org/0000-0003-0682-1574)
- Zengtuan Xiao (ORCID: https://orcid.org/0000-0003-0667-2353)
- Meng Yan (ORCID: https://orcid.org/0000-0002-0540-4720)
- Liu Zuo (ORCID: https://orcid.org/0009-0004-3081-9102)
- Yanbo Di
Institutions
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Gansu Provincial Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1186/s12885-025-15188-4
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00