Photostimulation of skull bone marrow modulates neuroimmunity in sepsis-associated encephalopathy via the skull bone marrow-dura mater-brain axis
We demonstrate that 50 mW IR can be safely confined to the SBM, effectively modulating skull, meningeal, and brain immunity to protect neurons in SAE mice. This study establishes SBM-restricted IR photobiomodulation as a safe and effective strategy to reprogram neuroimmune responses, highlighting the SBM-DM-B Axis as a novel pathway for neuroimmune regulation and a promising target for non-invasive interventions in SAE and other acute brain injuries.
Authors
- Yutao Du (ORCID: https://orcid.org/0000-0001-8564-1250)
- Tao Liu (ORCID: https://orcid.org/0000-0002-4202-8218)
- Xiaochang Xue (ORCID: https://orcid.org/0000-0001-9875-9821)
- Y B Li (ORCID: https://orcid.org/0009-0003-6395-678X)
- Fanfan Ye (ORCID: https://orcid.org/0009-0008-5549-2926)
- Guodong Feng (ORCID: https://orcid.org/0000-0002-3622-5848)
- Hanxiao Cai
- Yicheng Li (ORCID: https://orcid.org/0000-0002-4707-0917)
- Wenmian Huang
Institutions
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Shaanxi Normal University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1186/s12974-025-03617-x
- Citations
- 1
- Primary Topic
- Laser Applications in Dentistry and Medicine
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- National Science Foundation
- National Natural Science Foundation of China