Ion-interference amplifier nano-system enhances radiotherapy via mitochondrial dysfunction and efferocytosis Inhibition
This study presents a novel "ion-interference amplifier" strategy that concurrently enhances radiosensitization and immune response, offering a powerful model for synergistic radio-immunotherapy. Meanwhile, the integration of MRI-based tracking further underscores its potential for clinical translation.
Authors
- Bingxia Zhao (ORCID: https://orcid.org/0000-0003-1095-5719)
- Guoqiang Liu (ORCID: https://orcid.org/0000-0002-7757-2520)
- Zede Wu
- Chenggong Yan (ORCID: https://orcid.org/0000-0002-2968-4595)
- Chenxi He (ORCID: https://orcid.org/0009-0006-5812-7380)
- Shuting Zheng
- Yinfei Zheng (ORCID: https://orcid.org/0000-0001-6837-2634)
- Minyi Liu (ORCID: https://orcid.org/0000-0003-3959-1891)
- Meirong Hou (ORCID: https://orcid.org/0000-0001-9680-2830)
- Yikai Xu (ORCID: https://orcid.org/0000-0002-9785-3346)
- Honglei Hu (ORCID: https://orcid.org/0000-0002-4655-6288)
Institutions
- Chinese Academy of Sciences (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Key Laboratory of Guangdong Province (CN)
- Nanfang Hospital (CN)
- Institute of Electrical Engineering (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1186/s12951-025-03808-x
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province