Improving the efficiency of drug resistant tuberculosis treatment trials: a time-to-event alternative marker for bacteriological response and adaptive minimization for randomization
Using a model of mycobacterial burden changes over time as an alternative indicator of treatment response, combined with a minimization procedure during the randomization process, significantly reduced the sample size which could, if validated, enhance the efficiency of RR-TB clinical trial design.
Authors
- Annelies Van Rie (ORCID: https://orcid.org/0000-0001-7666-3263)
- Elise De Vos (ORCID: https://orcid.org/0000-0002-8019-4030)
- Steven Abrams (ORCID: https://orcid.org/0000-0001-7353-9304)
Institutions
- University of Antwerp (BE)
- Province of Antwerp (BE)
- Instituut voor Tropische Geneeskunde (BE)
- Hasselt University (BE)
Publication Details
- Journal
- BMC Medical Research Methodology
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1186/s12874-025-02697-w
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fonds Wetenschappelijk Onderzoek
- Vlaamse regering