Lycii radicis cortex alleviates fibrosis in hiPSC-derived multilineage hepatic organoids via the cAMP-PKA pathway
LRC exhibits potent anti-fibrotic activity in a physiologically relevant human organoid model, providing mechanistic insight into HSC regulation and supporting its potential as a candidate therapy for chronic liver disease. Furthermore, this study introduces a translational platform integrating animal models and hiPSC-derived organoids to facilitate anti-fibrotic drug discovery and evaluation.
Authors
- Xiaopu Sang
- Junming Xu (ORCID: https://orcid.org/0000-0002-9687-5551)
- Xiaoni Chen
- Jicai Wang
- Tanbin Liu
- Yongfei He (ORCID: https://orcid.org/0000-0001-8813-1416)
- Jie Ke (ORCID: https://orcid.org/0000-0001-5002-1676)
- Xianjie Shi (ORCID: https://orcid.org/0000-0001-7712-2258)
- Fenfang Wu (ORCID: https://orcid.org/0000-0001-5588-8199)
- Jiasen Xu
- Hang Zhai
Institutions
- Sun Yat-sen University (CN)
- Beijing University of Chinese Medicine (CN)
- Hubei University of Chinese Medicine (CN)
- Shenzhen Third People’s Hospital (CN)
- Eighth Affiliated Hospital of Sun Yat-sen University
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-25
- DOI
- https://doi.org/10.3389/fphar.2025.1730255
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- SENSHIN Medical Research Foundation
- Basic and Applied Basic Research Foundation of Guangdong Province