Overexpression of Sterol Regulatory Element-binding Transcription Factor 2 is associated with an adverse prognosis in cytogenetically normal acute myeloid leukemia
Our study identified SREBF2 as a novel prognostic biomarker in CN-AML. Through gene enrichment and microRNA network analysis, SREBF2 interactions with genomic/transcriptomic elements were found to drive CN-AML pathogenesis, providing clinical insights for treatment strategies.
Authors
- Cong Feng (ORCID: https://orcid.org/0000-0002-4855-0023)
- Ruo-Qi Shan
- Man Song
- Fang Pang
- Lili Dong (ORCID: https://orcid.org/0000-0002-6286-3528)
- Qiling Liu (ORCID: https://orcid.org/0000-0002-3479-5601)
- Jia‐Chi Wang (ORCID: https://orcid.org/0000-0002-1095-1091)
- Sai Huang (ORCID: https://orcid.org/0000-0003-0823-1412)
- Yaowei Liu (ORCID: https://orcid.org/0000-0002-4674-676X)
- Ping Chen (ORCID: https://orcid.org/0000-0001-6944-0192)
- Ran Zhang (ORCID: https://orcid.org/0000-0002-0921-078X)
- Xia Li (ORCID: https://orcid.org/0000-0001-8665-7983)
- Tingting Wu (ORCID: https://orcid.org/0000-0002-7836-6040)
- Ruoling Yang
- Yujun Wei (ORCID: https://orcid.org/0000-0001-5587-2680)
Institutions
- Nankai University (CN)
- Chinese PLA General Hospital (CN)
- Beijing Children’s Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1007/s12672-025-03846-9
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00