Is the combination of Myelodysplastic syndromes and pulmonary fibrosis accidental or inevitable?
MTHFR, IFIH1, PCSK9 and CTC1 are involved in key pathways including folate metabolism, immune regulation, inflammatory responses and telomere disorders, which may contribute to the pathogenesis of both MDS and pulmonary fibrosis. The coexistence of these two conditions is likely attributed to complex interactions among multiple gene mutations, environmental triggers, and dysregulated immune processes, rather than a single.
Authors
- Jie Chen (ORCID: https://orcid.org/0000-0002-0110-1706)
- Yang He (ORCID: https://orcid.org/0000-0002-9241-5101)
- Yuanyuan Wang (ORCID: https://orcid.org/0000-0003-0240-1521)
- Haiying Chen (ORCID: https://orcid.org/0000-0003-2841-5518)
- Yunxia Zhao (ORCID: https://orcid.org/0000-0002-2253-2484)
- Yahua Li (ORCID: https://orcid.org/0000-0002-9668-6697)
- Jinqiao Zhang
Institutions
- Hebei Medical University (CN)
- Third Hospital of Hebei Medical University (CN)
- Kingmed Diagnostics (CN)
Publication Details
- Journal
- Multidisciplinary Respiratory Medicine
- Published
- 2025-11-25
- DOI
- https://doi.org/10.5826/mrm.2025.1056
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00