A bibliometric analysis on immunotherapy treatments for systemic lupus erythematosus: analysis of published evidence from 2014 to 2024

This scientometric evaluation of 374 scholarly works emphasizes the critical importance of transnational collaborations among premier research institutions and developed nations in propelling SLE immunotherapy innovation. This bibliometric analysis reveals research trends and unmet needs in SLE immune therapies, guiding biologics development and precision medicine through core pathway identification and optimized trial designs. Key Points • Global research mapping: Identification of the USA (141 articles) and Harvard University (31 articles) as the predominant national and institutional contributors, respectively. • Intellectual structure analysis: Co-citation network clustering revealed ten principal research domains, including forkhead box P3, ICIs, n6-methyladenosine, and antiphospholipid syndrome, delineating the foundational knowledge structure. • Emerging frontiers detection: Temporal keyword analysis pinpointed evolving research priorities such as low-dose interleukin 2 (burst strength: 3.05), double-blind trials (strength: 3.2), and primary Sjögren's syndrome (strength: 3.13). • Strategic implications: The study underscores the critical role of transnational collaborations in advancing SLE immunotherapy innovation and highlights unmet needs guiding future biologics development and precision medicine approaches through core pathway identification and optimized trial designs.