LCRMP-1 induces tumor angiogenesis by transcriptionally upregulating SERPINE1 in lung adenocarcinoma

Angiogenesis is a crucial process in cancer progression, particularly in malignant tumors, as it facilitates tumor growth and metastasis by generating new blood vessels that supply vital nutrients and oxygen. However, the regulatory mechanism governing the development of these tumor neo-vessels by endothelial cells is still not fully understood. This study investigates the role of long-form collapsin response mediator protein-1 (LCRMP-1) in angiogenesis within non-small cell lung cancer (NSCLC). Through in vitro tube formation, in vivo plaque angiogenesis assays, and immunohistochemical staining, we identify SERPINE1 as a crucial factor regulated by LCRMP-1. Mechanistically, LCRMP-1 functions as a co-transcriptional factor, enhancing the expression of SERPINE1 through its interactions with TP53. This enhancement promotes the secretion of SERPINE1, alters the tumor microenvironment, and assists endothelial cells in the formation of new blood vessels, thereby further advancing the progression of NSCLC.

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Journal
Communications Biology
Published
2025-11-25
DOI
https://doi.org/10.1038/s42003-025-09071-y
Primary Topic
Axon Guidance and Neuronal Signaling
Type
article
Field-Weighted Citation Impact
0.00

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article

LCRMP-1 induces tumor angiogenesis by transcriptionally upregulating SERPINE1 in lung adenocarcinoma

Szu‐Hua Pan, Pan‐Chyr Yang, Chi-Chung Wang, Xuan‐Ren Chen et al.
Communications Biology
Axon Guidance and Neuronal Signaling
article

LCRMP-1 induces tumor angiogenesis by transcriptionally upregulating SERPINE1 in lung adenocarcinoma

Szu‐Hua Pan, Pan‐Chyr Yang, Chi-Chung Wang, Xuan‐Ren Chen, Pei‐Shan Wu, Chen‐Tu Wu, Yih‐Leong Chang, Tse-Ming Hong, Yuan-Ling Hsu, Pei-Fang Hung
article en

Abstract

Angiogenesis is a crucial process in cancer progression, particularly in malignant tumors, as it facilitates tumor growth and metastasis by generating new blood vessels that supply vital nutrients and oxygen. However, the regulatory mechanism governing the development of these tumor neo-vessels by endothelial cells is still not fully understood. This study investigates the role of long-form collapsin response mediator protein-1 (LCRMP-1) in angiogenesis within non-small cell lung cancer (NSCLC). Through in vitro tube formation, in vivo plaque angiogenesis assays, and immunohistochemical staining, we identify SERPINE1 as a crucial factor regulated by LCRMP-1. Mechanistically, LCRMP-1 functions as a co-transcriptional factor, enhancing the expression of SERPINE1 through its interactions with TP53. This enhancement promotes the secretion of SERPINE1, alters the tumor microenvironment, and assists endothelial cells in the formation of new blood vessels, thereby further advancing the progression of NSCLC.

Communications BiologyVol. 8(1)
Fu Jen Catholic University (TW), National Taiwan University (TW), Chang Gung University (TW), Taipei Veterans General Hospital (TW), Mackay Medical University (TW), Research Center for Information Technology Innovation, Academia Sinica (TW), Genomics Research Center, Academia Sinica (TW), National Taiwan University Hospital (TW), Academia Sinica (TW), National Cheng Kung University (TW)
Academia Sinica, National Taiwan University, National Science and Technology Council
Openalex Percentile: Top 61%
Axon Guidance and Neuronal Signaling
DOIOpen Access PDFOpenAlex
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