First-of-Its-Kind PPARG Inhibitor Shows Compelling Activity

A novel inhibitor of the protein PPARG, which is overexpressed in most cases of advanced urothelial carcinoma, led to tumor shrinkage in most patients with high PPARG expression who received the drug FX-909. In addition, some responding patients had elevated levels of CD4+ T cells and circulating chemokines and cytokines, suggesting that the drug attenuates PPARG-mediated immune suppression.

Publication Details

Journal
Cancer Discovery
Published
2025-11-25
DOI
https://doi.org/10.1158/2159-8290.cd-nw2025-0103
Primary Topic
Peroxisome Proliferator-Activated Receptors
Type
article
Field-Weighted Citation Impact
0.00
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article

First-of-Its-Kind PPARG Inhibitor Shows Compelling Activity

Cancer Discovery
Peroxisome Proliferator-Activated Receptors
article

First-of-Its-Kind PPARG Inhibitor Shows Compelling Activity

article en

Abstract

A novel inhibitor of the protein PPARG, which is overexpressed in most cases of advanced urothelial carcinoma, led to tumor shrinkage in most patients with high PPARG expression who received the drug FX-909. In addition, some responding patients had elevated levels of CD4+ T cells and circulating chemokines and cytokines, suggesting that the drug attenuates PPARG-mediated immune suppression.

Cancer DiscoveryVol. 16(1)
Openalex Percentile: Top 67%
Peroxisome Proliferator-Activated Receptors
DOISourceOpenAlex
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First-of-Its-Kind PPARG Inhibitor Shows Compelling Activity · Cancer Discovery (2025) | TGRS Research Map | TGRS