GH replacement therapy in adults stimulates fibroblast activation protein-α activity
(1) Our study documents for the first time that GH stimulates FAPα activity in vivo in human subjects. (2) The concomitant increase in collagen turnover and the lack of change in intact FGF21 suggest that GH-driven FAPα activity predominantly involves collagen breakdown, and (3) FAPα is a novel biomarker of GH/IGF-I activity and may be causally linked to GH-induced fibrosis.
Authors
- A. K. Pedersen (ORCID: https://orcid.org/0000-0002-3202-2269)
- Amanda Bæk (ORCID: https://orcid.org/0009-0005-1500-5466)
- Mai Christiansen Arlien-Søborg (ORCID: https://orcid.org/0000-0001-8424-558X)
- Mette Bjerre (ORCID: https://orcid.org/0000-0002-5511-8829)
- Niels Jessen (ORCID: https://orcid.org/0000-0001-5613-7274)
- Tine Borum Billeskov (ORCID: https://orcid.org/0000-0002-7885-7288)
- Ole L. Dollerup (ORCID: https://orcid.org/0000-0001-6924-7114)
- Jens Otto Lunde Jørgensen (ORCID: https://orcid.org/0000-0001-7408-1526)
Institutions
- Steno Diabetes Centers (DK)
- Aarhus University (DK)
- Aarhus University Hospital (DK)
Publication Details
- Journal
- European Journal of Endocrinology
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1093/ejendo/lvaf244
- Citations
- 1
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 1.05