Modular continuous flow synthesis of zidovudine (AZT): a two-stage integrated process enabling safe azidation and enhanced sustainability in HIV drug manufacturing
The two-stage integrated continuous flow synthesis of zidovudine ( AZT ) was accomplished, addressing the core challenges in converting zidovudine synthesis from batch to fully flow, particularly concerning solvent and reagent compatibility.
Authors
- Rongkun Jiang (ORCID: https://orcid.org/0000-0002-4488-021X)
- Yufang F. Xu (ORCID: https://orcid.org/0000-0003-4946-4722)
- Yan Chen (ORCID: https://orcid.org/0000-0002-9950-684X)
- Xuhong Qian (ORCID: https://orcid.org/0000-0003-0394-1968)
- Fang Zhao (ORCID: https://orcid.org/0000-0003-0570-7729)
- Weiping Zhu (ORCID: https://orcid.org/0000-0002-7622-5295)
Institutions
- East China University of Science and Technology (CN)
- East China Normal University (CN)
Publication Details
- Journal
- Reaction Chemistry & Engineering
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1039/d5re00370a
- Primary Topic
- Innovative Microfluidic and Catalytic Techniques Innovation
- Type
- article
- Field-Weighted Citation Impact
- 0.00