Design, synthesis, and antifungal activity of 14-aryloxy/amide substituted andrographolide derivatives
In order to find more compounds with antifungal activities, a series of new compounds were designed and synthesized using the natural product of diterpenoid lactones, andrographolide, as the parent nucleus. Target compounds were identified by <sup>1</sup>H NMR, <sup>13</sup>C NMR and/or HR-MS. The bioassay results demonstrated that compound 4d exhibited inhibition rates of over 60% against six fungal strains at 100 µg/mL, and the EC<sub>50</sub> value of 4d against P. piricola was only 9.09 µg/mL. SEM test showed that 4d could damage the mycelia of P. piricola. obviously. Moreover, 4d had no effect on cowpea seed germination, showing high safety.
Authors
- Jingyue Ma (ORCID: https://orcid.org/0000-0002-1972-8451)
- Yunying Sha
- Yuyan Zhou (ORCID: https://orcid.org/0000-0002-8528-3526)
- Zhuqing Liu (ORCID: https://orcid.org/0000-0002-5225-1771)
- Zhuyun Liu (ORCID: https://orcid.org/0000-0003-2747-4647)
- Lizhong Wang (ORCID: https://orcid.org/0000-0002-3571-8771)
- Shanshan Yang (ORCID: https://orcid.org/0009-0003-6203-8653)
Institutions
- Nantong University (CN)
- The Affiliated Taizhou People's Hospital of Nanjing Medical University (CN)
- Taizhou Vocational and Technical College (CN)
Publication Details
- Journal
- Scientific Reports
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1038/s41598-025-25907-3
- Primary Topic
- Andrographolide Research and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Government of Jiangsu Province