Proton Pump Inhibitor Use and Survival in Patients With Newly Diagnosed Glioblastoma
In this meta-analysis of patients with newly diagnosed glioblastoma, PPI use was associated with inferior survival outcomes. These findings suggest that PA-PPI use should be discouraged in patients with glioblastoma, since alternative agents are available and a detrimental effect cannot be excluded. Translational research studies should explore whether PPI-induced activity of ALDH mediates the potential adverse effects of PPI in glioblastoma. .
Authors
- Warren Mason (ORCID: https://orcid.org/0000-0001-9107-2242)
- Michael Weller (ORCID: https://orcid.org/0000-0002-1748-174X)
- Debaleena Sain
- John H. Sampson (ORCID: https://orcid.org/0000-0002-0104-7658)
- Thierry Gorlia
- Patrick Roth (ORCID: https://orcid.org/0000-0003-3897-214X)
- Roger Stupp (ORCID: https://orcid.org/0000-0002-5483-3118)
- Sara Erridge (ORCID: https://orcid.org/0000-0003-3411-2505)
- Matthias Preusser (ORCID: https://orcid.org/0000-0003-3541-2315)
- David A. Reardon (ORCID: https://orcid.org/0000-0001-6674-0157)
- Timothy F. Cloughesy (ORCID: https://orcid.org/0000-0002-8656-7483)
- J.C. Reijneveld
- Burt Nabors (ORCID: https://orcid.org/0000-0001-5926-2230)
- Émilie Le Rhun (ORCID: https://orcid.org/0000-0002-9408-3278)
- Wolfgang Wick
- Giuseppe Caracciolo Minniti (ORCID: https://orcid.org/0000-0003-1239-1603)
Institutions
- Harvard University (US)
- University of California, Los Angeles (US)
- Duke University (US)
- German Cancer Research Center (DE)
- University of Toronto (CA)
- University of Zurich (CH)
- Heidelberg University (DE)
- Policlinico Umberto I (IT)
- University Hospital Heidelberg (DE)
- Edinburgh Cancer Research (GB)
- Princess Margaret Cancer Centre (CA)
- University of Alabama at Birmingham (US)
- University Hospital of Zurich (CH)
- Center for Neuro-Oncology (US)
- Amsterdam Neuroscience (NL)
- Dana-Farber Cancer Institute (US)
- European Organisation for Research and Treatment of Cancer (BE)
- Pediatric Brain Tumor Foundation (US)
- Stichting Epilepsie Instellingen Nederland (NL)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Medical University of Vienna (AT)
- Sapienza University of Rome (IT)
- University of Amsterdam (NL)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.45578
- Citations
- 1
- Primary Topic
- ATP Synthase and ATPases Research
- Type
- article
- Field-Weighted Citation Impact
- 0.81