Species-Dependent Structural Variations in Single-Domain Antibodies
Species-neutral framework constraints and species-tuned loop adaptations have practical implications for sdAb engineering, species selection, and conjugation strategies. These features are captured in MO-IISA, an open-access database of known-target sdAbs from different species.
Authors
- Marta Baselga (ORCID: https://orcid.org/0000-0003-2672-5790)
- Alberto J. Schuhmacher (ORCID: https://orcid.org/0000-0002-0136-1049)
- Víctor Manuel Medina Pérez (ORCID: https://orcid.org/0000-0003-0044-0615)
- Javier Sánchez-Prieto (ORCID: https://orcid.org/0009-0009-1985-6507)
Institutions
- Fundacion Agencia Aragonesa para la Investigacion y el Desarrollo (ES)
- Instituto de Investigación Sanitaria Aragón (ES)
Publication Details
- Journal
- Antibodies
- Published
- 2025-11-25
- DOI
- https://doi.org/10.3390/antib14040100
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00