Adverse effects of posaconazole on adrenal steroid biosynthesis: An integrative approach using FAERS-based pharmacovigilance and systematic review with meta-analysis of randomised controlled trials
This study supports a causal association between posaconazole and pseudoaldosteronism by integrating clinical data from FAERS and SR/MA. Clinicians should closely monitor serum potassium during posaconazole therapy and consider pseudoaldosteronism in patients with hypokalaemia.
Authors
- Yuki Nakano (ORCID: https://orcid.org/0000-0002-0235-7615)
- Nobuyuki Shimono
- Kazumasa Kotake (ORCID: https://orcid.org/0000-0001-9869-1177)
- Masanobu Uchiyama (ORCID: https://orcid.org/0000-0001-6385-5944)
- Yuki Asai (ORCID: https://orcid.org/0000-0002-1933-8592)
- Masayuki Murata (ORCID: https://orcid.org/0000-0003-4261-5030)
- Hirotsugu Hasuwa
Institutions
- Kyushu University (JP)
- Fukuoka University (JP)
- Kyushu University Hospital (JP)
- Mie University Hospital (JP)
- Fukui-ken Saiseikai Hospital (JP)
Publication Details
- Journal
- International Journal of Antimicrobial Agents
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1016/j.ijantimicag.2025.107676
- Citations
- 1
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 1.29