The association between magnesium levels and gout: evidence from Mendelian randomization, a Chinese cross-sectional study, and NHANES analysis
This multifaceted study provides novel evidence supporting a protective role of magnesium against gout. The underlying mechanism may involve magnesium's influence on uric acid or its anti-inflammatory effects. These hypotheses need to be clarified by further experimental and clinical studies.
Authors
- Yang Shao (ORCID: https://orcid.org/0000-0002-8491-3610)
- Junjun Luan
- Cong Ma (ORCID: https://orcid.org/0000-0002-7912-1424)
- Hua Zhou (ORCID: https://orcid.org/0000-0001-6508-7942)
- Yuxin Zhao (ORCID: https://orcid.org/0000-0003-4683-2681)
- Xiangnan Hao
- Xiangfei Cui (ORCID: https://orcid.org/0000-0002-3582-5331)
- R Feng (ORCID: https://orcid.org/0000-0003-3893-9366)
- Haoshen Feng
- Xu Yang (ORCID: https://orcid.org/0009-0004-2734-3203)
- Congcong Jiao (ORCID: https://orcid.org/0000-0003-2488-9740)
Institutions
- First Hospital of China Medical University (CN)
- Jinzhou Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-11-25
- DOI
- https://doi.org/10.3389/fnut.2025.1688095
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Liaoning Province
- Liaoning Revitalization Talents Program
- Shengjing Hospital