NAD+-Boosting Ameliorates Heme Protein–Mediated Acute Kidney Injury
These findings demonstrate the remarkable protective effects of NAD+-boosting by NMN in HP-AKI as revealed by a multitude of markers relevant to AKI. The reduction in NAD+ content in the kidney in HP-AKI may reflect the direct effects of heme proteins and/or heme. We suggest that these findings support current interest in NAD+-boosting as a therapeutic strategy in clinical AKI.
Authors
- Allan W. Ackerman
- Trace Christensen (ORCID: https://orcid.org/0000-0003-4862-6259)
- Karl A. Nath (ORCID: https://orcid.org/0000-0001-9869-5506)
- Luis A. Juncos (ORCID: https://orcid.org/0000-0002-4630-2747)
- Joseph P. Grande (ORCID: https://orcid.org/0000-0001-5674-1682)
- Anthony J. Croatt
- Raman Deep Singh (ORCID: https://orcid.org/0000-0002-1441-2722)
Institutions
- Mayo Clinic (US)
- Mayo Clinic in Arizona (US)
- Office of International Affairs (US)
- Mayo Clinic in Florida (US)
- University of Arkansas for Medical Sciences (US)
Publication Details
- Journal
- Kidney360
- Published
- 2025-11-25
- DOI
- https://doi.org/10.34067/kid.0000001032
- Primary Topic
- Heme Oxygenase-1 and Carbon Monoxide
- Type
- article
- Field-Weighted Citation Impact
- 0.00