Triglyceride to High-Density Lipoprotein Ratio and the Risk of Major Adverse Cardiovascular Events in a Non-Diabetic General Population

Objective This study aimed to investigate the role of the triglyceride to high-density lipoprotein cholesterol (TG / HDL-C) ratio for the prediction of major adverse cardiovascular events (MACEs) in non-diabetic individuals.Material and methods In total 88946 non-diabetic individuals were enrolled in the study. These individuals were divided into four groups according to the TG / HDL-C ratios. The clinical endpoints were composite MACEs and their subtypes, myocardial infarction and stroke. Cox proportional hazards regression models and restricted cubic spline (RCS) analysis were conducted to explore the relationship between the TG / HDL-C ratio and MACEs.Results Multivariable Cox proportional hazards analyses showed that a higher TG / HDL-C ratio was associated with an elevated risk of MACEs. Kaplan-Meier survival curve showed that participants in higher quartiles of TG / HDL-C ratio had a higher cumulative incidence of composite MACEs (p<0.0001). In addition, RCS analysis indicated that the TG / HDL-C ratio and composite MACEs followed a non-linear relationship (p<0.0001).Conclusions The TG / HDL-C ratio can serve as a prognostic marker of MACEs in non-diabetic individuals.