Cytochalasinols A and B, Two New Cytochalasins From the Fungus <i>Xylaria necrophora</i> SZSS1‐2‐2
Two new cytochalasins (1 and 2) were isolated from the fermentation products of the fungus Xylaria necrophora SZSS1-2-2, along with nine known compounds: compound 3, arbuschalasin B (4), cytochalasin C (5), cytochalasin D (6), 19,20-epoxycytochalasin C (7), 19,20-epoxycytochalasin D (8), cytochalasin R (9), cytochalasin D 13,14-epoxide (10), and arbuschalasin A (11). The structures and absolute configurations of these compounds were elucidated by spectroscopic analyses, electronic circular dichroism, and GIAO <sup>13</sup>C NMR computational methods. All isolated compounds were evaluated for their biological activities, and the results indicated that compounds 5-10 exhibited notable cytotoxic effects against the tested cell lines. However, none of the compounds showed antibacterial activity.
Authors
- Yang Yu (ORCID: https://orcid.org/0000-0001-8498-1755)
- Chen Sun
- Er‐Wei Li
- Shuai‐Ming Zhu
- You‐Zhi Zhang (ORCID: https://orcid.org/0000-0002-1686-8651)
- Yang Yi (ORCID: https://orcid.org/0000-0001-7196-7153)
- Chang‐Wei Li (ORCID: https://orcid.org/0000-0002-8998-1508)
- Yang Zhang (ORCID: https://orcid.org/0000-0002-9796-0790)
- Lixia Chen (ORCID: https://orcid.org/0000-0003-2196-1428)
- Xue Zhao (ORCID: https://orcid.org/0000-0002-0211-3549)
- Qian Luo (ORCID: https://orcid.org/0009-0000-3566-6126)
- Rui Xu (ORCID: https://orcid.org/0009-0009-2777-0391)
Institutions
- Shenyang Pharmaceutical University (CN)
- Chinese Academy of Sciences (CN)
- Academy of Military Medical Sciences (CN)
- Institute of Microbiology (CN)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1002/cbdv.202503213
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00