Optimizing lower intensity triplet therapy in acute myeloid leukemia: a practical guide
Venetoclax-based doublets with azacitidine or low dose cytarabine are the standard of care for the treatment of acute myeloid leukemia (AML) in older patients or those unfit for intensive chemotherapy. However, some patients do not attain complete remission, and over time, most patients relapse. Frontline triplet therapy incorporating a targeted therapy (FLT3, IDH or menin inhibitor) is an emerging treatment concept under investigation for this population. Initial triplet regimens have yielded encouraging composite complete remission and measurable residual disease negativity rates, enabling the transition to allogeneic stem cell transplantation for eligible patients. While effective, triplets are associated with myelosuppression and cytopenia-related toxicities, which can affect treatment tolerability and quality of life. In this review, we summarize the available evidence for triplet therapy in AML and offer our recommendations on the practical application of triplets in clinical practice, with particular focus on adjustments to dosing schedules in induction and continuation cycles. We also outline drug-specific adverse effects and interactions based on emerging clinical data to help guide the clinician, given the increasing use of novel combination therapies.
Authors
- Jacqueline Suen Garcia (ORCID: https://orcid.org/0000-0003-2118-6302)
- Jennifer Marvin‐Peek (ORCID: https://orcid.org/0000-0001-9595-1279)
- Andrew H. Wei (ORCID: https://orcid.org/0000-0002-7514-3298)
- Courtney Denton Dinardo (ORCID: https://orcid.org/0000-0001-9003-0390)
- Yasmin Abaza (ORCID: https://orcid.org/0000-0002-9156-7912)
- Wei‐Ying Jen (ORCID: https://orcid.org/0000-0002-9339-3362)
- Jessica K. Altman (ORCID: https://orcid.org/0000-0003-1987-1896)
- Naval Guastad Daver (ORCID: https://orcid.org/0000-0001-7103-373X)
- Joshua F. Zeidner (ORCID: https://orcid.org/0000-0002-9014-1514)
- Musa E. Yilmaz (ORCID: https://orcid.org/0000-0002-4498-4895)
- Ghayas C. Issa (ORCID: https://orcid.org/0000-0002-4339-8683)
- Curtis A. Lachowiez (ORCID: https://orcid.org/0000-0001-8506-0624)
- Nicholas James Short (ORCID: https://orcid.org/0000-0002-2983-2738)
Institutions
- University of North Carolina at Chapel Hill (US)
- The University of Texas MD Anderson Cancer Center (US)
- Oregon Health & Science University (US)
- Walter and Eliza Hall Institute of Medical Research (AU)
- Peter MacCallum Cancer Centre (AU)
- Dana-Farber Cancer Institute (US)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- UNC Lineberger Comprehensive Cancer Center
Publication Details
- Journal
- Blood Cancer Journal
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1038/s41408-025-01429-z
- Citations
- 1
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- Syndax Pharmaceuticals
- Servier