Preliminary identification of the MiR-548ah-5p/THBD axis for heart failure via DirectTarget causal framework and bioinformatics analysis
This study demonstrates the effectiveness of the DirectTarget framework in identifying putative miRNA target interactions, providing a valuable addition to existing approaches. To our knowledge, this is the first report that the miR-548ah-5p/THBD axis is a key regulatory axis in HF, suggesting a potential new avenue for further research.
Authors
- Xinyuan Cui (ORCID: https://orcid.org/0000-0002-0556-7191)
- Yanwen Wang (ORCID: https://orcid.org/0000-0001-8770-7073)
- Xiaomin Yang (ORCID: https://orcid.org/0000-0003-4923-517X)
- Na Yuan
- Guisheng Song (ORCID: https://orcid.org/0000-0002-7309-4170)
- Yixin Li (ORCID: https://orcid.org/0000-0003-1074-6239)
- Yanbo Zhang (ORCID: https://orcid.org/0000-0002-2421-157X)
- Jing Tian (ORCID: https://orcid.org/0000-0002-0306-1947)
- Jiaming Shuang
Institutions
- University of Minnesota (US)
- Shanxi Medical University (CN)
- University of Minnesota Medical Center (US)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1186/s40001-025-03549-5
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00