Quantitative proteomic analysis reveals key proteins involved in radiation-induced brain injury
This study provides valuable insights into the molecular mechanisms of RIBI by identifying key proteins and their associated pathways. The findings suggest that these proteins, particularly APOE and PHLDA3, could serve as potential biomarkers and therapeutic targets for clinical intervention in RIBI. These results not only enhance our understanding of RIBI's molecular pathology but also open new avenues for the development of targeted therapies to mitigate radiation-induced neurotoxicity.
Authors
- Huiling Qu (ORCID: https://orcid.org/0000-0003-0909-6267)
- Ying Yan (ORCID: https://orcid.org/0000-0002-3546-3991)
- Hao Wang (ORCID: https://orcid.org/0000-0002-3424-6522)
- Defu Yang (ORCID: https://orcid.org/0000-0002-0212-9882)
- Junshuang Wang
- Jing Liu (ORCID: https://orcid.org/0000-0002-0493-296X)
- Shuang Lv (ORCID: https://orcid.org/0000-0003-3622-4092)
- Ying Zhang (ORCID: https://orcid.org/0000-0003-0509-1098)
- Y. Li (ORCID: https://orcid.org/0009-0003-5197-9482)
- Ying Xu (ORCID: https://orcid.org/0000-0002-5523-4168)
Institutions
- Dalian Medical University (CN)
- Dalian University of Technology (CN)
- General Hospital of Shenyang Military Region (CN)
- Heze Municipal Hospital (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1371/journal.pone.0337608
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 0.00