Potential value of [68Ga]Ga-FAPI-46 PET in patients with metastatic urothelial carcinoma: a bi-centric analysis
[<sup>68</sup>Ga]Ga-FAPI-46 PET demonstrated higher regional detection rates than ceCT in UC patients, particularly for lymph node metastases. Compared to 2-[<sup>18</sup>F]FDG, it provided superior tumour-to-background contrast but detected slightly fewer lesions. [<sup>68</sup>Ga]Ga-FAPI-46 PET may complement established imaging in selected scenarios, although its role in routine UC staging remains investigational.
Authors
- Lena M. Unterrainer
- Alina Küper
- Claudia Kesch (ORCID: https://orcid.org/0000-0002-2656-2664)
- Can Aydogdu (ORCID: https://orcid.org/0009-0003-1486-183X)
- Rudolf Alexander Werner (ORCID: https://orcid.org/0000-0003-3372-6046)
- David Kersting (ORCID: https://orcid.org/0000-0002-8451-1830)
- Kim M. Pabst (ORCID: https://orcid.org/0000-0002-9234-0795)
- Adrien Holzgreve (ORCID: https://orcid.org/0000-0002-9566-8438)
- Jozefina Casuscelli (ORCID: https://orcid.org/0000-0002-9899-1986)
- Wolfgang P. Fendler (ORCID: https://orcid.org/0000-0002-5106-3584)
- Marcus Unterrainer (ORCID: https://orcid.org/0000-0002-8238-1198)
- Christian Georg Stief (ORCID: https://orcid.org/0000-0003-3291-9460)
- Boris Hadaschik (ORCID: https://orcid.org/0000-0002-1052-2692)
- Hans Peter Schmid (ORCID: https://orcid.org/0000-0001-9076-4466)
- Ken Herrmann
- Clemens C. Cyran (ORCID: https://orcid.org/0000-0001-5630-6242)
- Sophie C. Kunte (ORCID: https://orcid.org/0009-0003-3175-952X)
- Timo Bartel
Institutions
- LMU Klinikum (DE)
- Ihre-Radiologen (DE)
- Essen University Hospital (DE)
- Centre de Coopération Universitaire Franco-Bavarois (DE)
- Molecular Theranostics (United States) (US)
- West German Heart and Vascular Center Essen (DE)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1007/s00259-025-07674-5
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00