Atroposelective synthesis of isoquinolinone bearing two distinct C–N axes <i>via</i> cobalt-catalyzed enantioselective C–H activation/annulation
We report a Co/Salox-catalyzed atroposelective C-H activation/annulation process that concurrently constructs dual C-N stereogenic axes under mild conditions. By incorporating acyclic axial chirality into 1,3-biaxial scaffolds, we achieve diverse multi-axial chiral architectures, thereby expanding the synthetic application of Co(II)/Salox catalytic systems.
Authors
- Jingping Qü (ORCID: https://orcid.org/0000-0002-7576-0798)
- Yuhan Zhou (ORCID: https://orcid.org/0000-0002-1860-8669)
- Baomin Wang (ORCID: https://orcid.org/0000-0001-9058-4983)
- Wenkai Li (ORCID: https://orcid.org/0000-0003-1286-9427)
- Liling Fu (ORCID: https://orcid.org/0000-0001-6114-1788)
- Yongqiang Xu
Institutions
- Dalian University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1039/d5cc05883j
- Primary Topic
- Axial and Atropisomeric Chirality Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00