Genome-wide methylation changes upon Caco-2 cells exposure to undigested and digested titanium dioxide nanoparticles
TiO<sub>2</sub>NPs exposure causes DNA methylation changes that have a functional impact on intestinal cells, which differs with its physicochemical properties and digestion. NM-105 caused hypermethylation, unlike the other TiO<sub>2</sub>NPs. This study highlights DNA methylation relevance in assessing NMs' toxicity.
Authors
- Dora Rolo (ORCID: https://orcid.org/0000-0003-4327-2279)
- Célia Ventura (ORCID: https://orcid.org/0000-0002-0637-2222)
- Luı́s Vieira (ORCID: https://orcid.org/0000-0002-7703-1409)
- Henriqueta Louro (ORCID: https://orcid.org/0000-0001-9744-7332)
- Catarina Silva (ORCID: https://orcid.org/0000-0002-0864-2572)
- Maria João Silva (ORCID: https://orcid.org/0000-0002-6060-0716)
- Ana Valente
Institutions
- National Institute of Health Dr. Ricardo Jorge (PT)
- Universidade Nova de Lisboa (PT)
Publication Details
- Journal
- Epigenomics
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1080/17501911.2025.2593814
- Primary Topic
- Nanoparticles: synthesis and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00