Validation of a Standardized Metabo-Lipidomic Workflow for Human Conjunctival Impression Cytology Specimens
These results confirm the feasibility of metabo-lipidomic analysis using CIC specimens and demonstrate the comparability of the conjunctival metabolome between both eyes in healthy subjects. The use of successive CIC is a source of variability and the metabolome of conjunctival cells differs from that of tears. To facilitate biomarker research in clinical practice, we propose a standardized workflow for the metabo-lipidomic analysis of CIC specimens.
Authors
- Camille Dupuy (ORCID: https://orcid.org/0000-0003-0063-4380)
- Hélène Blasco (ORCID: https://orcid.org/0000-0001-6107-0035)
- Sophie Catanese (ORCID: https://orcid.org/0000-0001-6741-9402)
- Patrick Emond (ORCID: https://orcid.org/0000-0002-5324-2164)
- Raoul Kanav Khanna (ORCID: https://orcid.org/0000-0001-6032-1488)
- Pierre‐Jean Pisella (ORCID: https://orcid.org/0000-0002-9729-5444)
- Geoffroy Mortemousque (ORCID: https://orcid.org/0009-0004-1151-3175)
- A. Lefèvre
- Nattie Lecolier
Institutions
- Université de Tours (FR)
- Inserm (FR)
- Centre Hospitalier Universitaire de Tours (FR)
- Hôpital Bretonneau (FR)
Publication Details
- Journal
- American Journal of Ophthalmology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1016/j.ajo.2025.11.032
- Citations
- 1
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 1.88