Inflammatory profiles of transdiagnostic symptom dimensions in healthy females
We find preliminary evidence that different transdiagnostic psychiatric symptom dimensions map onto specific inflammatory profiles, both at baseline and after a stress induction. This represents a proof-of-principle for the use of data-driven and hypothesis-driven approaches to identify and link transdiagnostic factors with inflammatory changes, which may be of use to future studies with larger, clinical populations, or for testing in the context of stratified interventions.
Authors
- Muzaffer Kaşer (ORCID: https://orcid.org/0000-0002-1106-1613)
- Tim Dalgleish (ORCID: https://orcid.org/0000-0002-7304-2231)
- Caitlin Hitchcock (ORCID: https://orcid.org/0000-0002-2435-0713)
- Quentin Dercon (ORCID: https://orcid.org/0000-0001-8264-347X)
- Stacey L. Kigar (ORCID: https://orcid.org/0000-0003-2636-0648)
- Alicia Smith (ORCID: https://orcid.org/0000-0003-2808-3306)
- Camilla L. Nord (ORCID: https://orcid.org/0000-0002-9281-3417)
- Konstantinos Ioannidis (ORCID: https://orcid.org/0000-0002-1537-5425)
- Mary-Ellen Lynall (ORCID: https://orcid.org/0000-0002-1939-7525)
Institutions
- The University of Melbourne (AU)
- MRC Cognition and Brain Sciences Unit (GB)
- University of Cambridge (GB)
- Isle of Wight NHS Trust (GB)
- Wellcome Sanger Institute (GB)
- Cambridgeshire and Peterborough NHS Foundation Trust (GB)
- University of Southampton (GB)
- University College London (GB)
Publication Details
- Journal
- Brain Behavior & Immunity - Health
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1016/j.bbih.2025.101146
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00