Thymoquinone inhibited the chondrogenic differentiation of tendon-derived stem cells caused by tendon injury
These findings suggested that TQ inhibited the protein kinase RNA-like ER kinase/eukaryotic initiation factor 2/activating transcription factor 4/CCAAT/enhancer-binding protein homologous protein signaling pathway to alleviate ER stress, thereby reducing the chondrogenic differentiation of TDSCs, both <i>in vitro</i> and <i>in vivo</i>.
Authors
- Chang Liu (ORCID: https://orcid.org/0000-0001-6755-4831)
- Yunqi Liu (ORCID: https://orcid.org/0000-0003-3850-5381)
- Yijun Tu
- Yanyan Pan (ORCID: https://orcid.org/0000-0002-8737-6101)
- Hui Cai (ORCID: https://orcid.org/0000-0002-6584-2917)
Institutions
- Dalian University (CN)
- Dalian Municipal Central Hospital (CN)
Publication Details
- Journal
- World Journal of Stem Cells
- Published
- 2025-11-26
- DOI
- https://doi.org/10.4252/wjsc.v17.i11.112393
- Primary Topic
- Nigella sativa pharmacological applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00