HIF-1α modulates β-catenin pathway to enhance the survival and angiogenesis of PBMSCs under hypoxia environment
This study highlights the modulatory function of HIF-1α on PBMSCs <i>via</i> β-catenin-driven anti-apoptotic and angiogenic signaling cascade under hypoxia environment, offering a promising strategy for improving the therapeutic effectiveness PBMSCs-based transplantation after myocardial infarction.
Authors
- Pengzhen Wang (ORCID: https://orcid.org/0000-0002-6603-3206)
- Ping-ge Tian
- Aiqun Wang (ORCID: https://orcid.org/0000-0003-1283-753X)
- Pingping Zhu (ORCID: https://orcid.org/0000-0002-9045-2398)
- Rui Zhang
- Wei Yuan (ORCID: https://orcid.org/0000-0001-9171-0267)
- Jian Wu
Institutions
- Jinan University (CN)
Publication Details
- Journal
- World Journal of Stem Cells
- Published
- 2025-11-26
- DOI
- https://doi.org/10.4252/wjsc.v17.i11.112484
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94