CT-guided Lumbar Puncture for Intrathecal Nusinersen Injection in Patients with Spinal Muscular Atrophy: Technical Effectiveness, Safety, and Radiation Dose
CT-guided lumbar puncture for intrathecal nusinersen injection is a safe and effective technique, even in complex spinal anatomy. Dorsal spondylodesis increases procedural complexity. Tailored puncture level selection, optimized positioning, and dose-reduction strategies are essential for high success rates and minimal radiation. While CT guidance ensures excellent anatomical visualization, fluoroscopy may reduce radiation and procedure time; future comparative studies should define optimal modality selection.
Authors
- Christoph Kleinschnitz (ORCID: https://orcid.org/0000-0002-1650-8875)
- Marcel Opitz (ORCID: https://orcid.org/0000-0001-7455-8590)
- M Drews (ORCID: https://orcid.org/0009-0003-9825-3136)
- Tim Hagenacker (ORCID: https://orcid.org/0000-0002-3631-3450)
- Johannes Haubold (ORCID: https://orcid.org/0000-0003-4843-5911)
- Cornelius Deuschl (ORCID: https://orcid.org/0000-0001-9262-7289)
- Denise Bos (ORCID: https://orcid.org/0000-0002-9585-9787)
- Sebastian Zensen (ORCID: https://orcid.org/0000-0003-2997-0740)
- Laura Valentina Klüner (ORCID: https://orcid.org/0000-0001-7850-3589)
- Michael Forsting (ORCID: https://orcid.org/0000-0002-5584-9824)
- Daniel Rosok (ORCID: https://orcid.org/0009-0003-2776-6604)
- Yannick Laurent Thal
- Raya Ocker-Serger
Institutions
- University Hospital of Zurich (CH)
- Essen University Hospital (DE)
Publication Details
- Journal
- Clinical Neuroradiology
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1007/s00062-025-01590-9
- Primary Topic
- Neurogenetic and Muscular Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00