Nutrient Availability Dictates Cancer Metabolism–Based Therapeutic Responses to Nononcology Drugs
A high-throughput screening approach investigating drug vulnerabilities dependent on nutrient status supports repurposing FDA-approved compounds as metabolically informed therapies for next-generation oncometabolic precision medicine.
Authors
- Yu Suk Choi (ORCID: https://orcid.org/0000-0002-0241-0447)
- Hocheol Lim (ORCID: https://orcid.org/0000-0002-4678-8062)
- Jae Won Roh (ORCID: https://orcid.org/0000-0002-3692-1739)
- Soo‐Youl Kim (ORCID: https://orcid.org/0000-0002-4021-2206)
- Kun‐Liang Guan (ORCID: https://orcid.org/0000-0003-1892-0174)
- Joo‐Hyun Nam (ORCID: https://orcid.org/0000-0001-8300-6974)
- Tadayoshi Hashimoto (ORCID: https://orcid.org/0000-0003-3759-1214)
- W. Namkung (ORCID: https://orcid.org/0000-0002-1480-7433)
- Han-Sol Jeong (ORCID: https://orcid.org/0000-0001-9452-3010)
- Woo Yang Pyun (ORCID: https://orcid.org/0009-0008-7520-6077)
- Kyoung Tai No (ORCID: https://orcid.org/0000-0003-3187-8193)
- Heon Yung Gee (ORCID: https://orcid.org/0000-0002-8741-6177)
- Takayuki Yoshino (ORCID: https://orcid.org/0000-0002-0489-4756)
- Dongkyu Jeon (ORCID: https://orcid.org/0000-0002-1339-6388)
- Hyun Woo Park (ORCID: https://orcid.org/0000-0001-7736-2286)
- Ji Eun Paik (ORCID: https://orcid.org/0009-0003-8219-5090)
- Young Jin Jang (ORCID: https://orcid.org/0000-0003-0553-2498)
- Won Dong Lee (ORCID: https://orcid.org/0000-0002-2344-171X)
- S. Park (ORCID: https://orcid.org/0009-0007-5007-9094)
- Han‐Woong Lee (ORCID: https://orcid.org/0000-0001-9515-3605)
- Jae Hoon Lee (ORCID: https://orcid.org/0000-0001-9777-5918)
- Jongwan Kim (ORCID: https://orcid.org/0000-0003-1909-584X)
- Hyungwoo Kim (ORCID: https://orcid.org/0000-0002-1183-7434)
- Seok Chan Cho (ORCID: https://orcid.org/0009-0004-7764-2017)
- Jeong‐Wook Park (ORCID: https://orcid.org/0009-0005-8308-7416)
- D.S. Son (ORCID: https://orcid.org/0009-0005-0747-3016)
- J. H. Byun (ORCID: https://orcid.org/0009-0004-3479-3712)
Institutions
- The University of Western Australia (AU)
- Gyeongju University (KR)
- Yonsei University (KR)
- Dongguk University (KR)
- Korea University Medical Center (KR)
- Westlake University (CN)
- National Cancer Center (US)
- Institute of Molecular Sciences and Bioinformatics (PK)
- National Cancer Center (KR)
- Prosthetic Design + Research (United States) (US)
- National Cancer Center Hospital East (JP)
- Pusan National University (KR)
- Sungkyunkwan University (KR)
- Seoul Women's University (KR)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1158/0008-5472.can-25-1123
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00