Mechanism by which 24-week different-volume high-intensity interval training ameliorates renal fibrosis in naturally aging rats via regulating the TGF-β1/Smad pathway
24-week HIIT intervention can effectively delay the decline of renal function and the progression of renal fibrosis in naturally aging rats. Its protective effect may be associated with inhibiting the overactivation of the TGF-β1/Smad signaling pathway. High-volume HIIT (H1) induced a more profound suppression of the pro-fibrotic pathway, whereas low-volume HIIT (H2) represents a time-efficient strategy conferring notable protection at the phenotypic level.
Authors
- Wei He (ORCID: https://orcid.org/0000-0003-3410-0643)
- Kaiyu Cui (ORCID: https://orcid.org/0000-0002-3119-6072)
- John H. Zhang (ORCID: https://orcid.org/0000-0002-4319-4285)
- Hao Su (ORCID: https://orcid.org/0000-0003-0519-6471)
Institutions
- Beijing Sport University (CN)
Publication Details
- Journal
- Experimental Gerontology
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1016/j.exger.2025.112977
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00