Patterns of Longitudinal Regional Brain Atrophy in Patients With Different Progressive Supranuclear Palsy Clinical Variants
Regional patterns of brain atrophy differ across PSP clinical variants, although midbrain atrophy was common in all variants. Sample size estimates suggest that combining the PSP Rating Scale and targeted MRI volumes provides the optimum outcome measure for clinical treatment trials recruiting patients with PSP clinical variants.
Authors
- Clifford R. Jack (ORCID: https://orcid.org/0000-0001-7916-622X)
- Farwa Ali (ORCID: https://orcid.org/0000-0001-6060-3995)
- Keith A. Josephs (ORCID: https://orcid.org/0000-0003-2930-8634)
- Mahesh Kumar (ORCID: https://orcid.org/0000-0002-4198-5892)
- Stephen D. Weigand (ORCID: https://orcid.org/0000-0002-4541-9011)
- Mary M. Machulda (ORCID: https://orcid.org/0000-0003-4834-5967)
- Matthew L. Senjem (ORCID: https://orcid.org/0000-0001-9308-9275)
- Christopher G. Schwarz (ORCID: https://orcid.org/0000-0002-1466-8357)
- Yehkyoung C. Stephens (ORCID: https://orcid.org/0000-0003-0761-3283)
- Nirubol Tosakulwong
- Jennifer L. Whitwell (ORCID: https://orcid.org/0000-0001-6914-1563)
Institutions
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1212/wnl.0000000000214434
- Citations
- 1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39