Association of CSF Kappa-Free Light Chains With Cortical and Periventricular Brain Damage in Multiple Sclerosis
Higher κ-FLC levels were associated with both PVL burden and cortical pathology, regions adjacent to the CSF. Although this study was limited by a relative small sample size, our findings underscore the potential of κ-FLC as a diagnostic and prognostic MS biomarker.
Authors
- Daniela Pinter (ORCID: https://orcid.org/0000-0003-3138-5225)
- Sebastian Wurth (ORCID: https://orcid.org/0000-0001-7122-0842)
- Peter Opriessnig (ORCID: https://orcid.org/0000-0002-3768-7745)
- Sonja Hochmeister (ORCID: https://orcid.org/0000-0002-3925-6455)
- Rina Demjaha (ORCID: https://orcid.org/0000-0001-9725-9809)
- Bettina Heschl
- Christian Enzinger (ORCID: https://orcid.org/0000-0001-9764-7617)
- Lukas Pirpamer (ORCID: https://orcid.org/0000-0002-4390-9703)
- Anna Damulina (ORCID: https://orcid.org/0000-0001-8241-2727)
- Michael Khalil (ORCID: https://orcid.org/0000-0002-5350-3328)
- Stefan Ropele (ORCID: https://orcid.org/0000-0002-5559-768X)
- Edith Hofer (ORCID: https://orcid.org/0000-0003-2964-0987)
- Cansu Tafrali (ORCID: https://orcid.org/0009-0003-2910-3791)
- Juan-Jose Archelos
- Maria Martinez-Serrat
Institutions
- Statistics Austria (AT)
- Medical University of Graz (AT)
- Center For Biomarker Research In Medicine (AT)
- Centre d'Imagerie BioMedicale (CH)
Publication Details
- Journal
- Neurology
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1212/wnl.0000000000214433
- Citations
- 2
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.94