Host-guest complexes of cucurbituril with the neutral guest valrubicin: an experimental and computational study
The CB-VAL complex significantly enhanced physicochemical properties of VAL in aqueous solutions, with superiority for CB8. These results highlight the potential of CB7 and CB8 as novel drug delivery systems for hydrophobic drugs, offering a strategy to overcome the limitations of existing solubilization approaches in cancer therapy.
Authors
- Abdel‐Monem M. Rawashdeh (ORCID: https://orcid.org/0000-0001-9066-6073)
- Musa I. El‐Barghouthi (ORCID: https://orcid.org/0000-0003-1961-796X)
- Yazan H. Akkam
- Osama M. Abuhasan (ORCID: https://orcid.org/0000-0002-7373-8538)
- Yara N. Al-Shdifat
Institutions
- Hashemite University (JO)
- Yarmouk University (JO)
Publication Details
- Journal
- Drug Development and Industrial Pharmacy
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1080/03639045.2025.2595494
- Primary Topic
- Supramolecular Chemistry and Complexes
- Type
- article
- Field-Weighted Citation Impact
- 0.00